Sex Differences In The Gut Microbiota As Potential Determinants Of Gender Predisposition To Disease

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Sex Differences In The Gut Microbiota As Potential Determinants Of Gender Predisposition To Disease

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PROJECT TOPIC AND MATERIAL ON SEX DIFFERENCES IN THE GUT MICROBIOTA AS POTENTIAL DETERMINANTS OF GENDER PREDISPOSITION TO DISEASE

The Project File Details

  • Name: Sex Differences In The Gut Microbiota As Potential Determinants Of Gender Predisposition To Disease
  • Type: PDF and MS Word (DOC)
  • Size: [70 KB]
  • Length: [56] Pages

 

Scope

Dysbiosis of gut microbiota is involved in metabolic syndrome (MetS) development, which has a different incidence between men (M) and women (W). The differences in gut microbiota in MetS patients are explored according to gender, and whether consuming two healthy diets, Mediterranean (MED) and low‐fat (LF), may, over time, differentially shape the gut microbiota dysbiosis according to gender is evaluated.

Materials and Methods

All the women from the CORDIOPREV study whose feces samples were available and a similar number of men, matched by the main metabolic variables (N = 246, 123 women and 123 men), and categorized according to the presence or not of MetS are included. Gut microbiota is analyzed at baseline and after 3 years of dietary intervention.

Results

Higher abundance of CollinsellaAlistipesAnaerotruncus, and Phascolarctobacterium genera is observed in MetS‐W than in MetS‐M, whereas the abundance of Faecalibacterium and Prevotella genera is higher in MetS‐M than in MetS‐W. Moreover, higher levels of DesulfovibrioRoseburia, and Holdemania are observed in men than in women after the consumption of the LF diet.

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